Chronic Myeloid Leukemia (CML) - Multiple Choice Questions

Q.) The type of leukemia associated with basophilic Leukocytosis is

Chronic Myeloid leukemia

Acute Lymphoid leukemia

Acute myeloid leukemia

Chronic Lymphoid leukemia

Q.) Which chromosomal abnormality is diagnostic in CML?

Auer body

Philadelphia chromosome

Deletion of the short arm of chromosome 13

Trisomy of chromosome 21

Q.) The following is NOT a phase found in Chronic Myeloid Leukemia

Blast phase

Accelerated phase

Unstable phase

Stable phase

Q.) The feature NOT seen in Chronic Myeloid leukemia is

Thrombocytosis

Decreased leukocyte alkaline phosphatase

Leukocytosis

Absence of basophils

Q.) The hematological disorder which shows BCR-ABL fusion gene is

Chronic Myeloid leukemia

Polycythemia vera

Erythroleukemia

Von Willebrand disease

Q.) CML stands for

Chronic Megaloblastic Lymphoma

Chronic Megaloblastic Leukemia

Chronic Myelogenous Leukemia

Cold Myelogenous Leukemia

Q.) The most common translocation found in patients with chronic myelogenous leukemia is

t(8;21)

t(15;17)

t(9;22)

t(8;14)

Q.) The following statements is NOT TRUE with respect to Philadelphia chromosome

It is a balanced reciprocal translocation between long arm of chromosome 9 and chromosome 22

It is an acquired chromosomal abnormality present in all proliferating hematopoietic stem cells

It produces a new chimeric (fusion) gene called BCR-ABL

Its presence is a bad prognostic indicator

Q.) Which best describes the natural history of CML?

Diagnosis followed by a stable phase lasting several years that will progress into acute leukemia

Diagnosis followed by rapid disease progression

None of the Above

Diagnosis followed by nearly a decade of stable disease and then slow progression leading to death

Q.) The cytochemical stain which helps to differentiate leukemoid reaction from chronic myeloid leukemia is

Leukocyte alkaline phosphatase

Nonspecific esterase

Sudan Black

Periodic acid Schiff

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