Chronic Myeloid Leukemia (CML) - Multiple Choice Questions

Q.) The following statements is NOT TRUE with respect to Philadelphia chromosome

It produces a new chimeric (fusion) gene called BCR-ABL

Its presence is a bad prognostic indicator

It is an acquired chromosomal abnormality present in all proliferating hematopoietic stem cells

It is a balanced reciprocal translocation between long arm of chromosome 9 and chromosome 22

Q.) The following is NOT a phase found in Chronic Myeloid Leukemia

Stable phase

Blast phase

Accelerated phase

Unstable phase

Q.) The type of leukemia associated with basophilic Leukocytosis is

Chronic Lymphoid leukemia

Chronic Myeloid leukemia

Acute Lymphoid leukemia

Acute myeloid leukemia

Q.) The feature NOT seen in Chronic Myeloid leukemia is

Decreased leukocyte alkaline phosphatase

Thrombocytosis

Absence of basophils

Leukocytosis

Q.) CML stands for

Chronic Myelogenous Leukemia

Chronic Megaloblastic Leukemia

Cold Myelogenous Leukemia

Chronic Megaloblastic Lymphoma

Q.) Which best describes the natural history of CML?

Diagnosis followed by a stable phase lasting several years that will progress into acute leukemia

None of the Above

Diagnosis followed by rapid disease progression

Diagnosis followed by nearly a decade of stable disease and then slow progression leading to death

Q.) The cytochemical stain which helps to differentiate leukemoid reaction from chronic myeloid leukemia is

Sudan Black

Nonspecific esterase

Leukocyte alkaline phosphatase

Periodic acid Schiff

Q.) The hematological disorder which shows BCR-ABL fusion gene is

Chronic Myeloid leukemia

Von Willebrand disease

Polycythemia vera

Erythroleukemia

Q.) The most common translocation found in patients with chronic myelogenous leukemia is

t(9;22)

t(8;14)

t(8;21)

t(15;17)

Q.) Which chromosomal abnormality is diagnostic in CML?

Deletion of the short arm of chromosome 13

Trisomy of chromosome 21

Auer body

Philadelphia chromosome

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