Chronic Myeloid Leukemia (CML) - Multiple Choice Questions

Q.) The cytochemical stain which helps to differentiate leukemoid reaction from chronic myeloid leukemia is

Sudan Black

Periodic acid Schiff

Nonspecific esterase

Leukocyte alkaline phosphatase

Q.) Which chromosomal abnormality is diagnostic in CML?

Trisomy of chromosome 21

Philadelphia chromosome

Deletion of the short arm of chromosome 13

Auer body

Q.) The feature NOT seen in Chronic Myeloid leukemia is

Decreased leukocyte alkaline phosphatase

Leukocytosis

Absence of basophils

Thrombocytosis

Q.) CML stands for

Chronic Megaloblastic Leukemia

Cold Myelogenous Leukemia

Chronic Megaloblastic Lymphoma

Chronic Myelogenous Leukemia

Q.) The following statements is NOT TRUE with respect to Philadelphia chromosome

It is an acquired chromosomal abnormality present in all proliferating hematopoietic stem cells

Its presence is a bad prognostic indicator

It produces a new chimeric (fusion) gene called BCR-ABL

It is a balanced reciprocal translocation between long arm of chromosome 9 and chromosome 22

Q.) The type of leukemia associated with basophilic Leukocytosis is

Chronic Myeloid leukemia

Acute myeloid leukemia

Acute Lymphoid leukemia

Chronic Lymphoid leukemia

Q.) The most common translocation found in patients with chronic myelogenous leukemia is

t(15;17)

t(8;21)

t(8;14)

t(9;22)

Q.) The following is NOT a phase found in Chronic Myeloid Leukemia

Blast phase

Stable phase

Accelerated phase

Unstable phase

Q.) Which best describes the natural history of CML?

Diagnosis followed by rapid disease progression

Diagnosis followed by nearly a decade of stable disease and then slow progression leading to death

Diagnosis followed by a stable phase lasting several years that will progress into acute leukemia

None of the Above

Q.) The hematological disorder which shows BCR-ABL fusion gene is

Chronic Myeloid leukemia

Erythroleukemia

Von Willebrand disease

Polycythemia vera

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