Chronic Myeloid Leukemia (CML) - Multiple Choice Questions

Q.) The following statements is NOT TRUE with respect to Philadelphia chromosome

It produces a new chimeric (fusion) gene called BCR-ABL

It is a balanced reciprocal translocation between long arm of chromosome 9 and chromosome 22

It is an acquired chromosomal abnormality present in all proliferating hematopoietic stem cells

Its presence is a bad prognostic indicator

Q.) The feature NOT seen in Chronic Myeloid leukemia is

Thrombocytosis

Absence of basophils

Decreased leukocyte alkaline phosphatase

Leukocytosis

Q.) The type of leukemia associated with basophilic Leukocytosis is

Acute Lymphoid leukemia

Chronic Myeloid leukemia

Chronic Lymphoid leukemia

Acute myeloid leukemia

Q.) Which chromosomal abnormality is diagnostic in CML?

Philadelphia chromosome

Auer body

Deletion of the short arm of chromosome 13

Trisomy of chromosome 21

Q.) The hematological disorder which shows BCR-ABL fusion gene is

Erythroleukemia

Von Willebrand disease

Polycythemia vera

Chronic Myeloid leukemia

Q.) The following is NOT a phase found in Chronic Myeloid Leukemia

Blast phase

Stable phase

Unstable phase

Accelerated phase

Q.) CML stands for

Chronic Myelogenous Leukemia

Chronic Megaloblastic Leukemia

Cold Myelogenous Leukemia

Chronic Megaloblastic Lymphoma

Q.) The cytochemical stain which helps to differentiate leukemoid reaction from chronic myeloid leukemia is

Periodic acid Schiff

Sudan Black

Nonspecific esterase

Leukocyte alkaline phosphatase

Q.) The most common translocation found in patients with chronic myelogenous leukemia is

t(9;22)

t(15;17)

t(8;21)

t(8;14)

Q.) Which best describes the natural history of CML?

Diagnosis followed by nearly a decade of stable disease and then slow progression leading to death

None of the Above

Diagnosis followed by rapid disease progression

Diagnosis followed by a stable phase lasting several years that will progress into acute leukemia

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