Chronic Myeloid Leukemia (CML) - Multiple Choice Questions

Q.) The following statements is NOT TRUE with respect to Philadelphia chromosome

Its presence is a bad prognostic indicator

It is an acquired chromosomal abnormality present in all proliferating hematopoietic stem cells

It produces a new chimeric (fusion) gene called BCR-ABL

It is a balanced reciprocal translocation between long arm of chromosome 9 and chromosome 22

Q.) Which chromosomal abnormality is diagnostic in CML?

Trisomy of chromosome 21

Auer body

Deletion of the short arm of chromosome 13

Philadelphia chromosome

Q.) The cytochemical stain which helps to differentiate leukemoid reaction from chronic myeloid leukemia is

Nonspecific esterase

Leukocyte alkaline phosphatase

Periodic acid Schiff

Sudan Black

Q.) The hematological disorder which shows BCR-ABL fusion gene is

Polycythemia vera

Von Willebrand disease

Erythroleukemia

Chronic Myeloid leukemia

Q.) Which best describes the natural history of CML?

Diagnosis followed by a stable phase lasting several years that will progress into acute leukemia

Diagnosis followed by nearly a decade of stable disease and then slow progression leading to death

Diagnosis followed by rapid disease progression

None of the Above

Q.) The following is NOT a phase found in Chronic Myeloid Leukemia

Unstable phase

Stable phase

Blast phase

Accelerated phase

Q.) The most common translocation found in patients with chronic myelogenous leukemia is

t(9;22)

t(15;17)

t(8;14)

t(8;21)

Q.) The type of leukemia associated with basophilic Leukocytosis is

Acute myeloid leukemia

Chronic Myeloid leukemia

Chronic Lymphoid leukemia

Acute Lymphoid leukemia

Q.) The feature NOT seen in Chronic Myeloid leukemia is

Absence of basophils

Thrombocytosis

Leukocytosis

Decreased leukocyte alkaline phosphatase

Q.) CML stands for

Cold Myelogenous Leukemia

Chronic Megaloblastic Leukemia

Chronic Megaloblastic Lymphoma

Chronic Myelogenous Leukemia

Toggle embed code

Sending

User Review

4.29 (7 votes)

Laboratory Hub Team

Laboratory Hub aims to provide the Medical Laboratory Protocols & General Medical Information in the most easy to understand language so that the Laboratory Technologist can learn and perform various laboratory tests with ease. If you want any protocol to be published on Laboratory Hub, Please drop a mail at contact@laboratoryhub.com. Happy Learning!