Chronic Myeloid Leukemia (CML) - Multiple Choice Questions

Q.) The feature NOT seen in Chronic Myeloid leukemia is

Thrombocytosis

Decreased leukocyte alkaline phosphatase

Absence of basophils

Leukocytosis

Q.) The cytochemical stain which helps to differentiate leukemoid reaction from chronic myeloid leukemia is

Leukocyte alkaline phosphatase

Sudan Black

Periodic acid Schiff

Nonspecific esterase

Q.) Which chromosomal abnormality is diagnostic in CML?

Auer body

Trisomy of chromosome 21

Deletion of the short arm of chromosome 13

Philadelphia chromosome

Q.) The hematological disorder which shows BCR-ABL fusion gene is

Erythroleukemia

Polycythemia vera

Chronic Myeloid leukemia

Von Willebrand disease

Q.) The type of leukemia associated with basophilic Leukocytosis is

Chronic Lymphoid leukemia

Acute Lymphoid leukemia

Acute myeloid leukemia

Chronic Myeloid leukemia

Q.) Which best describes the natural history of CML?

Diagnosis followed by rapid disease progression

Diagnosis followed by a stable phase lasting several years that will progress into acute leukemia

None of the Above

Diagnosis followed by nearly a decade of stable disease and then slow progression leading to death

Q.) CML stands for

Chronic Megaloblastic Leukemia

Chronic Megaloblastic Lymphoma

Chronic Myelogenous Leukemia

Cold Myelogenous Leukemia

Q.) The following is NOT a phase found in Chronic Myeloid Leukemia

Blast phase

Unstable phase

Stable phase

Accelerated phase

Q.) The most common translocation found in patients with chronic myelogenous leukemia is

t(8;14)

t(8;21)

t(9;22)

t(15;17)

Q.) The following statements is NOT TRUE with respect to Philadelphia chromosome

It is a balanced reciprocal translocation between long arm of chromosome 9 and chromosome 22

It produces a new chimeric (fusion) gene called BCR-ABL

Its presence is a bad prognostic indicator

It is an acquired chromosomal abnormality present in all proliferating hematopoietic stem cells

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