Chronic Myeloid Leukemia (CML) - Multiple Choice Questions

Q.) Which chromosomal abnormality is diagnostic in CML?

Auer body

Deletion of the short arm of chromosome 13

Philadelphia chromosome

Trisomy of chromosome 21

Q.) CML stands for

Chronic Megaloblastic Leukemia

Chronic Myelogenous Leukemia

Cold Myelogenous Leukemia

Chronic Megaloblastic Lymphoma

Q.) The most common translocation found in patients with chronic myelogenous leukemia is

t(15;17)

t(8;21)

t(9;22)

t(8;14)

Q.) Which best describes the natural history of CML?

None of the Above

Diagnosis followed by a stable phase lasting several years that will progress into acute leukemia

Diagnosis followed by nearly a decade of stable disease and then slow progression leading to death

Diagnosis followed by rapid disease progression

Q.) The hematological disorder which shows BCR-ABL fusion gene is

Von Willebrand disease

Chronic Myeloid leukemia

Erythroleukemia

Polycythemia vera

Q.) The cytochemical stain which helps to differentiate leukemoid reaction from chronic myeloid leukemia is

Periodic acid Schiff

Sudan Black

Nonspecific esterase

Leukocyte alkaline phosphatase

Q.) The feature NOT seen in Chronic Myeloid leukemia is

Absence of basophils

Thrombocytosis

Decreased leukocyte alkaline phosphatase

Leukocytosis

Q.) The type of leukemia associated with basophilic Leukocytosis is

Chronic Myeloid leukemia

Acute Lymphoid leukemia

Acute myeloid leukemia

Chronic Lymphoid leukemia

Q.) The following statements is NOT TRUE with respect to Philadelphia chromosome

It is a balanced reciprocal translocation between long arm of chromosome 9 and chromosome 22

Its presence is a bad prognostic indicator

It is an acquired chromosomal abnormality present in all proliferating hematopoietic stem cells

It produces a new chimeric (fusion) gene called BCR-ABL

Q.) The following is NOT a phase found in Chronic Myeloid Leukemia

Accelerated phase

Blast phase

Unstable phase

Stable phase

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