Chronic Myeloid Leukemia (CML) - Multiple Choice Questions

Q.) The hematological disorder which shows BCR-ABL fusion gene is

Erythroleukemia

Polycythemia vera

Von Willebrand disease

Chronic Myeloid leukemia

Q.) CML stands for

Cold Myelogenous Leukemia

Chronic Megaloblastic Lymphoma

Chronic Myelogenous Leukemia

Chronic Megaloblastic Leukemia

Q.) Which chromosomal abnormality is diagnostic in CML?

Deletion of the short arm of chromosome 13

Philadelphia chromosome

Trisomy of chromosome 21

Auer body

Q.) Which best describes the natural history of CML?

Diagnosis followed by nearly a decade of stable disease and then slow progression leading to death

Diagnosis followed by a stable phase lasting several years that will progress into acute leukemia

None of the Above

Diagnosis followed by rapid disease progression

Q.) The most common translocation found in patients with chronic myelogenous leukemia is

t(8;14)

t(8;21)

t(9;22)

t(15;17)

Q.) The cytochemical stain which helps to differentiate leukemoid reaction from chronic myeloid leukemia is

Sudan Black

Leukocyte alkaline phosphatase

Nonspecific esterase

Periodic acid Schiff

Q.) The type of leukemia associated with basophilic Leukocytosis is

Chronic Lymphoid leukemia

Acute myeloid leukemia

Acute Lymphoid leukemia

Chronic Myeloid leukemia

Q.) The following is NOT a phase found in Chronic Myeloid Leukemia

Unstable phase

Stable phase

Blast phase

Accelerated phase

Q.) The following statements is NOT TRUE with respect to Philadelphia chromosome

It is an acquired chromosomal abnormality present in all proliferating hematopoietic stem cells

It produces a new chimeric (fusion) gene called BCR-ABL

Its presence is a bad prognostic indicator

It is a balanced reciprocal translocation between long arm of chromosome 9 and chromosome 22

Q.) The feature NOT seen in Chronic Myeloid leukemia is

Thrombocytosis

Decreased leukocyte alkaline phosphatase

Absence of basophils

Leukocytosis

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